Looking at the line again, it's funny if taken out of context, but for the record, I wanted to state that Najimi was the unwitting benefactor of lulz, like, oh I don't know, William Hung.
Doujin Work has appeal because it's outrageous. Perhaps it's not outrageous as it could have been, but there's still plenty of shameless elements. It's outrageously cheap looking for one (and a show stopper for many), with just enough drawn (and animated) to support the dialog that carries the show. The screws of misunderstanding are turned in over the top fashion but generally manage to remain fresh given that an episode is half the typical length.
The series stumbles at the end, trying to connect back to the (ludicrous) premise that got everything started in the first place. Najimi was in it for the money, and then over the course of the series began playing for pride, although she never admits that it's nigh impossible for someone of her skill level to earn a living. When confronted with the unlikely possibility, she rejects it and we are treated to a short statement about work ethic. Morality tales may be meaningful, but they certainly aren't outrageous.
I won't be taking anything away from Doujin Work except the ED, but there's something endearing about something so
ghetto looking, for mostly nostalgic reasons. And because it may have inspired the following: